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Comparison of Methyllidocaine and Lidocaine on Arrhythmias Produced by Coronary Occlusion in the Dog
1973
Circulation
Methyllidocaine, a quarternary ammonium derivative of lidocaine, was tested as a treatment for the ventricular ectopic beats occurring in unanesthetized dogs 24 hours after two-stage ligation of the anterior descending branch of the left coronary artery. The electrocardiogram (lead II) and electroencephalogram were recorded. Methyllidocaine (4 and 8 mg/kg) injected i.v. during a 1-min period produced a significant reduction in ectopic beats with no significant increase in EEG activity.
doi:10.1161/01.cir.47.4.697
pmid:4696791
fatcat:ub5fw2cgyzbfhendjianmorks4