Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations

P J Norman, C V F Carrington, M Byng, L D Maxwell, M D Curran, H A F Stephens, D Chandanayingyong, D H Verity, K Hameed, D D Ramdath, R W Vaughan
2002 Genes and Immunity  
Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs) , which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two major
more » ... the two major ethnic groups (eg KIR2DS4 gene frequency 0.82 African, 0.47 S Asian. P c Ͻ 1 × 10 −6 ) and this is due to uneven distribution of two KIR haplotype families 'A' and 'B'. All three populations described here displayed a greater degree of diversity of KIR genetic profiles than other populations investigated, which indicates further complexity of underlying haplotypes; in this respect we describe two individuals who appear homozygous for a large deletion including the previously ubiquitous 2DL4. We have also reanalysed three populations that we studied previously, for the presence of a KIR which is now known to be an indicator of the 'B' haplotype. South Asians had the highest overall frequencies of all KIR loci characteristic of 'B' haplotypes (P c Ͻ 0.0001 to Ͻ 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations. Genes and Immunity (2002) 3, 86-95.
doi:10.1038/sj.gene.6363836 pmid:11960306 fatcat:xsgpvotj6ncznixm5cw56nq77a