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Genes and Immunity
Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs) , which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two majordoi:10.1038/sj.gene.6363836 pmid:11960306 fatcat:xsgpvotj6ncznixm5cw56nq77a