High Visfatin Expression in Breast Cancer Tissue Is Associated with Poor Survival

Y.-C. Lee, Y.-H. Yang, J.-H. Su, H.-L. Chang, M.-F. Hou, S.-S. F. Yuan
2011 Cancer Epidemiology, Biomarkers and Prevention  
Adipocytokines, adipocyte-secreted hormones, play a critical role in breast cancer development. The expression of visfatin, a newly discovered adipocytokine, in breast cancer tissues was determined and correlated with patient clinicopathologic variables. Methods: Visfatin expression in breast cancer tissues was analyzed by immunohistochemistry. Visfatin expression was correlated with clinicopathologic variables as well as recurrence rates, using the c 2 test. The prognostic value of visfatin
more » ... alue of visfatin for disease-free and overall survival was evaluated by Kaplan-Meier estimates, and the significance of differences between curves was evaluated by the log-rank test. Results: High visfatin expression in breast cancer tissues was significantly correlated with tumor size, estrogen receptor (ER) negativity, and progesterone receptor (PR) negativity. Hormone therapy, but not radiotherapy or chemotherapy, decreased the recurrence rate in patients with high visfatin expression. Whereas high visfatin expression alone was associated with poor disease-free and overall survival, worse disease-free and overall survival was observed when high visfatin expression was combined with ER-and PRnegative status. Cox regression analysis also revealed that visfatin is an independent predictor of disease-free and overall survival.
doi:10.1158/1055-9965.epi-11-0399 pmid:21784959 fatcat:n33vnbadera53iiwm7kcfctl4u