Effects of an Antithrombin Drug in Patients with Subacute Exacerbations of Binswanger Disease

Hidekazu TOMIMOTO, Ichiro AKIGUCHI, Ryo OHTANI, Hideo YAGI, Satoshi OGURA, Hideaki WAKITA
2000 Internal medicine (Tokyo. 1992)  
The blood coagulation system has been shown to be activated in subacute exacerbations of Binswanger disease (BD). In our previous study, the antithrombin drug argatroban ameliorated the neurological exacerbations in a BDpatient with antiphospholipid antibody syndrome. We have further examined the therapeutic efficacy of argatroban in 3 BDpatients with subacute exacerbations, but without any immune-mediated prothrombotic complications. In 1 out of these 4 patients, treatment with sodium ozagrel,
more » ... an antiplatelet drug was applied, but was ineffective. In all patients, argatroban treatment reduced the levels of the hemostatic markers, with a corresponding improvement in cognitive dysfunction and gait disorders. These results suggest that the antithrombin effect is true also for BDpatients not compromised by the immune-mediated prothrombotic condition. (Internal Medicine 39: 966-969, 2000)
doi:10.2169/internalmedicine.39.966 fatcat:3jztsevlgbekpedywzom6r6ujy