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CRISPR-Cas-amplified urine biomarkers for multiplexed and portable cancer diagnostics
Synthetic biomarkers, exogenous probes that generate molecular reporters, represent an emerging paradigm in precision diagnostics with applications across infectious and noncommunicable diseases. In order to achieve their promise, these methods reply on multiplexing strategies to provide tools that are both sensitive and specific. However, the field of synthetic biomarkers has not benefited from molecular strategies such as DNA-barcoding due to the susceptibility of nucleic acids in vivo.doi:10.1101/2020.06.17.157180 fatcat:yymxwmi73ngqrdoqqr2hyvjjqi