Type 2 diabetes is primarily associated with insulin resistance and β-cell dysfunction. Maintenance of functional mature β-cells is imperative for ensuring glucose homeostasis. This can be achieved by optimal expression of key transcription factors that are required for normal pancreatic development and maintaining β-cell function. Defining the regulation of transcription factors as well as their regulation of important β-cell genes like insulin will provide further insight into elucidating the mechanisms leading to β-cell dysfunction.