Personalized Medicine in Cardiovascular Diseases

Moo-Sik Lee, Andreas J. Flammer, Lilach O. Lerman, Amir Lerman
2012 Korean Circulation Journal  
There has been a remarkable progress of personalized medicine in the scientific basis and clinical applications on cardiovascular diseases (CVDs) after its introduction in the late 1990s. However, CVDs still remains the leading cause of death in the United States. Moreover, there will be needs on the education to doctors and patients for the improvement of knowledge, awareness and attitude on incorporating such method into clinical applications. Personalized medicine will contribute to the
more » ... tion of the management practice for CVDs. This article reviews the concepts, the strength, limitations and challenges, and future direction of personalized medicine with a particular focus on CVDs. Personalized medicine is a novel medical model with all decisions and practices being tailored to individual patients in whatever ways possible. In the era of genomics, personalized medicine combines the genetic information for additional benefit in preventive and therapeutic strategies. Personalized medicine may allow the physician to provide a better therapy for patients in terms of efficiency, safety and treatment length to reduce the associated costs. There was a remarkable growth in scientific publication on personalized medicine within the past few years in the cardiovascular field. However, so far, only very few cardiologists in the USA are incorporating personalized medicine into clinical treatment. We review the concepts, strengths, limitations and challenges of personalized medicine with a particular focus on cardiovascular diseases (CVDs). There are many challenges from both scientific and policy perspectives to personalized medicine, which can overcome them by comprehensive concept and understanding, clinical application, and evidence based practices. Individualized medicine serves a pivotal role in the evolution of national and global healthcare reform, especially, in the CVDs fields. Ultimately, personalized medicine will affect the entire landscape of health care system in the near future. (Korean Circ J 2012;42:583-591)
doi:10.4070/kcj.2012.42.9.583 pmid:23091501 pmcid:PMC3467440 fatcat:uq34zmavpzh3tltoknkr5qtw2i