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Chang Gung Med J
To investigate intrinsic alterations in ovarian steroidogenesis in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS) who ovulated after metformin treatment. Methods: Fifty-six women of reproductive age (18-40 years) diagnosed with CC-resistant PCOS received metformin for 12 weeks. If ovulation was successfully induced by CC after metformin treatment, the women were classified as responders. Circulating levels of follicle-stimulating hormone (FSH), luteinizing hormonefatcat:wa6dl6qesjexlaqbqrg6t66kje