Chemical Similarity Networks for Drug Discovery [chapter]

Yu-Chen Lo, Jorge Z. Torres
2016 Special Topics in Drug Discovery  
Chemical similarity networks are an emerging area of interest in medicinal chemistry, chemical biology, and systems chemoinformatics that are currently being applied to drug target prediction, drug repurposing, and drug discovery in the new paradigm of poly-pharmacology and systems biology. In this chapter, we discuss the network-based drug target identification and discovery framework called chemical similarity network analysis pull-down (CSNAP) and its applications. We highlight the utility
more » ... CSNAP in identifying novel antimitotic drugs and their targets through practical case studies.
doi:10.5772/65106 fatcat:4hmygfcwt5honi7u5maxjnqc4i