Pyelonephrities is the urinary tract infection. Using supplemental dugs may decrease duration of treatment and hospitalization. We studied the effect of vitamin C on the recovery of symptoms due to pyelonephrities Methods and Materials: In this clinical trial, double blind, study, 64 patients with uncomplicated pyelonephrities were assessed in 2 groups randomly. Case group took vitamin C capsules, and control group took placebo capsules. In both groups, primary treatment was ceftriaxon capsules

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... during hospitalization and they took ciprofloxacin capsules for 14 days after discharging. Symptoms and Urinary analysis were assessed in the first day of administration and then on the 7 th and 14 th days after discharging. Data were analyzed with Chi-Square test. Results: Mean of fever duration in vitamin C group (1.13±0.34 SD day) and placebo group (1.56±0.62 SD day) significantly decrease (p=0.001). There was a significant difference in dysuria duration in vitamin C group 2.19±1.06 SD day with placebo group (2.97±1.06 SD day) (p =0.007). In flank pain, nausea and vomiting duration difference was not significantly (p≥ 0.05). Conclusion: It seems vitamin C, as a supplementary drug improves some pyelonephrities symptoms, such as fever and dysuria, decreases of the hospitalization period.