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Proceedings for Annual Meeting of The Japanese Pharmacological Society
The anterior cingulate cortex (ACC) is important for emotional and cognitive processing. However, the mechanisms that underlyingie the its involvement of the ACC in the control of behavioral responses are largely unknown. Here, we show that fatty acid-binding protein 3 (FABP3), a polyunsaturated fatty acid chaperone, regulates GABA synthesis through transcriptional regulation of Gad67 in the ACC and that methionine restores normal Gad67 expression and behaviors in Fabp3 knockout mice. Futuredoi:10.1254/jpssuppl.92.0_3-p-024 fatcat:secwqvwhijfqpfuwpcni4f6phm