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Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping
In budding yeast, Cdc13, Stn1, and Ten1 form the telomere-binding heterotrimer CST complex. Here we investigate the role of Cdc13/CST in maintaining genome stability by using a Chr VII disome system that can generate recombinants, chromosome loss, and enigmatic unstable chromosomes. In cells expressing a temperature sensitive CDC13 allele, cdc13F684S, unstable chromosomes frequently arise from problems in or near a telomere. We found that, when Cdc13 is defective, passage through S phase causesdoi:10.1371/journal.pgen.1008733 pmid:32287268 fatcat:qmmgcsqf55c5phfkrldhjpzmwu