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Modern DNA sequencing has instituted a new era in human cytomegalovirus (HCMV) genomics. A key development has been the ability to determine the genome sequences of HCMV strains directly from clinical material. This involves the application of complex and often non-standardized bioinformatics approaches to analysing data of variable quality in a process that requires substantial manual intervention. To relieve this bottleneck, we have developed GRACy (Genome Reconstruction and Annotation ofdoi:10.1093/ve/veaa099 pmid:33505707 pmcid:PMC7816668 fatcat:xu7nf2rkujfwlfr77dxry5aqqi