A comparative study on the raft chemical properties of various alginate antacid raft-forming products

Peter W. Dettmar, Diana Gil-Gonzalez, Jeanine Fisher, Lucy Flint, Daniel Rainforth, Antonio Moreno-Herrera, Mark Potts
2017 Drug Development and Industrial Pharmacy  
Objective: Research to measure the chemical characterization of alginate rafts for good raft performance and ascertain how formulation can affect chemical parameters. Significance: A selection of alginate formulations was investigated all claiming to be proficient raft formers with significance between products established and ranked. Methods: Procedures were selected which demonstrated the chemical characterization allowing rafts to effectively impede the reflux into the esophagus or in severe
more » ... cases to be refluxed preferentially into the esophagus and exert a demulcent effect, with focus of current research on methods which complement previous studies centered on physical properties. The alginate content was analyzed by a newly developed HPLC method. Methods were used to determine the neutralization profile and the acid neutralization within the raft determined along with how raft structure affects neutralization. Results: Alginate content of Gaviscon Double Action (GDA) within the raft was significantly superior (p < .0001) to all competitor products. The two products with the highest raft acid neutralization capacity were GDA and Rennie Duo, the latter product not being a raft former. Raft structure was key and GDA had the right level of porosity to allow for longer duration of neutralization. Conclusion: Alginate formulations require three chemical reactions to take place simultaneously: transformation to alginic acid, sodium carbonate reacting to form carbon dioxide, calcium releasing free calcium ions to bind with alginic acid providing strength to raft formation. GDA was significantly superior (p <.0001) to all other comparators. ARTICLE HISTORY
doi:10.1080/03639045.2017.1371737 pmid:28836872 fatcat:grzb3u5a6jbdlivwarfxcwt6h4