Primary hypoparathyroidism in a patient with common variable immunodeficiency associated enteropathy

Rashad Ismayilov, Ilgin Yildirim Simsir, Deniz Akyol, Fatma Omur Ardeniz
2020 Romanian Journal Of Internal Medicine  
Common variable immunodeficiency (CVID) is a rare disease characterized by humoral immunodeficiency, often causing sinopulmonary and gastrointestinal infections, and may cause enteropathy in some patients, which leads to severe malnutrition and electrolyte deficiencies. Although many autoimmune diseases are seen with increased frequency in CVID patients, primary hypoparathyroidism is extremely rare. A 50-year-old man with CVID presented with diarrhea. The patient had complaints for 2 years and
more » ... as cachectic. He had severe electrolyte and vitamin deficiencies that did not respond to oral treatment. The diarrhea causes such as celiac, inflammatory bowel diseases, and gastrointestinal infections were excluded and the endoscopy showed enteropathic changes in the duodenum and colon. Concomitant hypoparathyroidism was also detected in the patient with hypocalcemia despite adequate replacement. Parenteral therapy should be considered in the management of CVID enteropathy cases that do not respond to oral replacement. Although very rare, hypoparathyroidism should be considered in the differential diagnosis of CVID patients with treatment-resistant hypocalcemia.
doi:10.2478/rjim-2020-0030 pmid:33098635 fatcat:6cotv75kibb7nehyyrjuiy4dze