Studies on the Chemical Constituents of Stem Bark of Millettia leucantha: Isolation of New Chalcones with Cytotoxic, Anti-herpes Simplex Virus and Anti-inflammatory Activities

Ampai Phrutivorapongkul, Vimolmas Lipipun, Nijsiri Ruangrungsi, Kanyawim Kirtikara, Kiyohiro Nishikawa, Sakiko Maruyama, Toshiko Watanabe, Tsutomu Ishikawa
2003 Chemical and pharmaceutical bulletin  
The genus Millettia WEIGHT et ARN. (Leguminosae) consists of ca. 100 old world species of climbers and trees, and their seeds and other parts are in some cases known to show insecticidal and piscicidal properties. 1) In previous studies 2) flavonoids, isoflavonoids and alkaloids were isolated as chemical components. M. leucantha KURZ is a lofty tree, with pinnate leaves and white flowers, growing throughout Thailand 3) ; however, its medicinal use is unknown. The present investigation deals
more » ... the isolation of chalcone derivatives (1, 2, 4, 6, 7, 10) including four new ones (1, 4, 7, 10) and flavones (3, 5, 8, 9, 11) from the stem bark, and their cytotoxic, antiviral and anti-inflammatory activities.
doi:10.1248/cpb.51.187 pmid:12576653 fatcat:zlwuzpnfabarxanbkkievcfdq4