Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents

Robert B. P. Elmes, Marialuisa Erby, Sandra A. Bright, D. Clive Williams, Thorfinnur Gunnlaugsson
2012 Chemical Communications  
The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Tro¨ger's bases, are described; these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation. Scheme 1 The synthesis of the bis-Ru(II)polypyridyl naphthalimide complexes 1 and 2. (i) Paraformaldehyde, TFA. (ii) Ru(bpy) 2 Cl 2 , DMSO/H 2 O, microwave irradiation (See full
more » ... (See full experimental details in ESIw).
doi:10.1039/c2cc17274g pmid:22293955 fatcat:mvmcbajzivdb3jxmb2bblhbk7m