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Neurokinin Concentrations in Cerebrospinal Fluid. A Preliminary Study in Parkinson's Disease

R. Galard, R. Catalán, J. Montalbán, A. Molins, F. Miquel, J. M. Castellanos, Humboldt-Universität Zu Berlin, Humboldt-Universität Zu Berlin
2017

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Immunoreactive neurokinin A was measured in the cerebrospinal fluid of twelve patients with Parkinson's disease and eleven normal subjects, using a sensitive and precise extraction/concentration radioimmunoassay method. The mean value obtained in Parkinson's disease patients (13.2 ± 4.6 pmol/1) was lower than that of the controls (17.4 ± 5.9). The tendency toward a significant decrease (p = 0.085) found in this preliminary study could indicate that neurokinin Α-containing neurons are involved
more » ... the pathophysiology of Parkinson's disease. In addition, the establishment of reference values for neurokinin A in cerebrospinal fluid may provide a basis for further studies of this neuropeptide in neurological disorders.
doi:10.18452/11067 fatcat:oyvstoazsbaydafzqryjj5blle
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R. Galard, R. Catalán, J. Montalbán, A. Molins, F. Miquel, J. M. Castellanos, Humboldt-Universität Zu Berlin, Humboldt-Universität Zu Berlin. "Neurokinin Concentrations in Cerebrospinal Fluid. A Preliminary Study in Parkinson's Disease." (2017)