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Single-nucleotide polymorphism (SNP) analysis is a powerful tool for mapping and diagnosing disease-related alleles. Mutation analysis by polymerase-mediated single-base primer extension (minisequencing) can be massively parallelized using DNA microchips or¯ow cytometry with microspheres as solid support. By adding a unique oligonucleotide tag to the 5¢ end of the minisequencing primer and attaching the complementary antitag to the array or bead surface, the assay can be'demultiplexed'. Suchdoi:10.1093/nar/gkg267 pmid:12626722 pmcid:PMC152869 fatcat:ounwe47xsjaa7n4tnx6d3wkr7a