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Development of a genetically-encoded oxytocin sensor
[article]
2020
bioRxiv
pre-print
Oxytocin (OXT) is a neuropeptide originating in the paraventricular nucleus (PVN) of the hypothalamus, with a role in influencing various social behaviors. However, pinpointing its actions only during the time animals are performing specific behaviors has been difficult to study. Here we developed an optogenetic gene expression system designed to selectively label neuronal populations activated by OXT in the presence of blue-light, named OXTR-iTango2. The OXTR-iTango2 was capable of inducing
doi:10.1101/2020.07.14.202598
fatcat:mlvmhan7mzblrbagi563uipzee