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Advances and Applications in Bioinformatics and Chemistry
Genotoxic stress is induced by a broad range of DNA-damaging agents and could lead to a variety of human diseases including cancer. DNA damage is also therapeutically induced for cancer treatment with the aim to eliminate tumor cells. However, the effectiveness of radio-and chemotherapy is strongly hampered by tumor cell resistance. A major reason for radio-and chemotherapeutic resistances is the simultaneous activation of cell survival pathways resulting in the activation of the transcriptionfatcat:hflqpuwtpvepzjxr6ioszweakq