In Silico: Analysis of the Potential of Bromelain, Zingibain and Papain as an Alternative Medicine for Fungal Keratitis

Nugraha Wahyu Cahyana
2022 Zenodo  
Fungal keratitis is an acute or chronic inflammation of the cornea caused by fungi. The main treatment for fungal keratitis is Natamycin 5%. Disadvantages of natamycin are its poor penetration and increased resistance due to fungi which lower the level of ergosterol in its wall. Purpose: Investigates the effect of bromelain, zingibain and papain on LOX-1 receptors in fungal keratitis caused by Aspergillus fumigatus. Result: The LOX-1 receptor with bromelain produces a binding energy value of
more » ... 7.8. While the results of docking LOX-1 receptors with zingibain resulted in a binding energy value of -1096.3. Furthermore, the results of docking the LOX-1 receptor with papain resulted in a binding energy value of -900.0. Conclusion: zingibain has the highest potency among the three enzymes Papain as an Alternative Medicine for Fungal Keratitis
doi:10.5281/zenodo.7414215 fatcat:tdkuenxogzc4zo5dp4cjsipkma