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Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS
2020
International Journal of Molecular Sciences
The presence of abnormal ovarian ratios of myo-inositol (MI) to D-chiro-inositol (DCI) is a recurrent feature in PCOS. Available evidence suggests that MI and DCI may modulate steroid biosynthesis, likely in an opposite manner. Specifically, MI seems to induce estrogen production, while DCI has a role in the synthesis of androgens. Elevated insulin levels, generally associated with PCOS, alter the physiological MI/DCI ratio, increasing MI-to-DCI conversion through activation of a specific
doi:10.3390/ijms21197157
pmid:32998310
fatcat:3sfgwa3c5jaqnmerhg32fvd2mq