BACKGROUND Poorly controlled blood glucose levels accelerate hyperglycaemia, induces excess free radical generation, and causes Oxidative stress. Thereby it is a condition of increased Oxidative stress and it requires antioxidants. The total antioxidants provide greater protection against damage caused by reactive oxygen species or reactive nitrogen species, than any single compound alone. Thus, overall antioxidant capacity may provide more relevant biological information compared to that

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... ed by the measurement of individual components. Aims and Objectives-To evaluate whether Total Antioxidant Capacity and Malondialdehyde can be used for early screening of Oxidative Stress, and its correlation with HbA1c of both cases and controls. MATERIALS AND METHODS Study was conducted at a Tertiary Care Hospital. 50 T2DM patients were taken as cases of 40-60 age group, with 50 healthy subjects of similar age group. TAC, MDA and HbA1c of both cases and controls were assessed. Statistical Analysis-Statistical Analysis done using SPSS 20 version software. RESULTS The mean HbA1c levels are higher in Cases {7.09 ± 0.38}% than in Controls {4.55 ± 0.41}% [p value-< 0.001 ]. The mean TAC is decreased in Cases-{1.28 ± 0.19} mM than in Controls-{2.3 ± 0.18} mM [p value-< 0.001], and an increase in MDA level is noted in Cases {2.11 ± 0.34} than in Controls {0.74 ± 0.13} nmol/mL [p value-< 0.001]. A negative correlation of TAC of Cases {-0.959, p value-<0.001} & Controls {-0.991, p value-<0.001} is noted, and a positive correlation of MDA of Cases {0.624, p value -<0.001} & Controls {0.936, p value-0.001} are noted with respect to HbA1c. CONCLUSION The above assays could be employed to detect complications early and revert the conditions to a certain extent. This would increase the longevity and quality of life of patients with diabetes.