Effects of Mixed Nut Consumption on LDL Cholesterol and Lipoprotein(a) in Overweight and Obese Adults

Chelsea Nora, Sotirios Tsimikas, Tiffany Lum, Mee Young Hong
2020 Current Developments in Nutrition  
Objectives Elevated levels of LDL cholesterol (LDL-C) and lipoprotein(a) [Lp(a)] are associated with a greater risk for atherosclerotic cardiovascular events. Consumption of individual types of nuts has been shown to decrease these risk factors but limited knowledge is known about the effect of mixed nuts on Lp(a). Very few studies have evaluated the effect of mixed nut consumption on LDL-C levels in an obese and overweight population, while even fewer studies have examined the effects of a
more » ... he effects of a dietary intervention on Lp(a). The objective of this study was to determine if 69 g/d of mixed nut consumption would decrease serum LDL-C and Lp(a) levels in obese and overweight individuals. Methods In a randomized-controlled 16-week study, 29 obese or overweight (BMI 25–40 kg/m2, age 27.6 years) participants were asked to consume either 69 g of mixed nuts/d (n = 15) or 42.5 g of isocaloric-matched Snyder's unsalted pretzels/d (n = 14). Blood samples were collected at baseline, week 8, and week 16 for analysis of total cholesterol (TC), LDL-C, HDL-C, oxidized-LDL (OxLDL), triglyceride (TG) and Lp(a). Results There were no significant differences in TC, LDL-C, HDL-C, OxLDL, or Lp(a) when comparing the two intervention diets. Participants consuming mixed nuts had significantly higher (P = 0.007) serum TGs when compared to the pretzel group at week 8 but differences were not significant at week 16. Conclusions Consumption of mixed nuts (69 g/d) had no effect on LDL-C or Lp(a) levels over a 16-week dietary intervention in an obese or overweight population. Future direction should focus on increasing sample size and/or testing for confounding traits (i.e., polymorphisms, metabolic syndrome, or predispositions to elevated LDL-C levels). Funding Sources American Heart Association (16GRNT31360007).
doi:10.1093/cdn/nzaa045_077 fatcat:7l3aazy7ifgvvaqb4hxnhw7t4a