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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells
[article]
2022
bioRxiv
pre-print
AbstractLong-term reconstituting haematopoietic stem cells (LT-HSCs) are used to treat blood disorders via allogeneic stem cell transplantation (alloSCT), to engraft and repopulate the blood system. The very low abundance of LT-HSCs and their rapid differentiation during in vitro culture hinders their clinical utility. Previous developments using stromal feeder layers, defined media cocktails, and bioengineering have enabled HSC expansion in culture, but of mostly short-term HSCs (ST-HSC) and
doi:10.1101/2022.07.28.501818
fatcat:2ebiuq4zsvbtdmrvacz53slrla