5-Hydroxytryptamine-1 receptor activation inhibits endocrine pancreatic secretion in humans

Bernard Coulie, Jan Tack, Roger Bouillon, Theo Peeters, Jozef Janssens
1998 American Journal of Physiology. Endocrinology and Metabolism  
5-Hydroxytryptamine-1 receptor activation inhibits endocrine pancreatic secretion in humans. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E317-E320, 1998.-The selective 5-hydroxytryptamine-1 receptor agonist sumatriptan inhibits exocrine pancreatic function in humans. No data are available on the effect of sumatriptan on fasting and postprandial endocrine pancreatic function in humans. To elucidate the influence of 5-hydroxytryptamine-1 receptor activation by sumatriptan on endocrine pancreatic
more » ... ndocrine pancreatic function and blood glucose homeostasis, we determined plasma levels of somatostatin, glucagon, pancreatic polypeptide, insulin, and C-peptide before and after subcutaneous administration of sumatriptan (6 mg) in seven healthy volunteers, and we measured blood glucose and insulin plasma levels during an oral glucose tolerance test after placebo and after subcutaneous administration of sumatriptan (6 mg) in seven healthy volunteers. Sumatriptan significantly decreased the mean plasma levels of somatostatin, glucagon, pancreatic polypeptide, insulin and C-peptide (P Ͻ 0.001) and also significantly decreased mean and peak plasma levels of insulin after an oral glucose challenge (P Ͻ 0.02 and P ϭ 0.04, respectively) without affecting glucose homeostasis. From our study, we speculate that activation of the 5-hydroxytryptamine-1 receptor inhibits endocrine pancreatic secretion. enteropancreatic innervation Fig. 2 . Plasma insulin levels during oral glucose challenge test after placebo (j) and after 6 mg sc sumatriptan (r) given at time 0.
doi:10.1152/ajpendo.1998.274.2.e317 fatcat:2kw53yragbf7rf2mypuwo3jee4