Assoziation von Polymorphismen des CREB1-Gens mit Veränderungen der N1-Amplitude im EEG als Endophänotyp der Schizophrenie [article]

Grit Büchner-Mögling, Ulrich Hegerl, Jürgen Gallinat, Ina Giegling, Martin-Luther Universität, Universitäts- Und Landesbibliothek Sachsen-Anhalt
There is evidence for a strong genetic component in the aetiology of schizophrenia. CREB1 gene is one of these possible susceptibility genes. EEG disturbances are among the most consistently observed endophenotypes in schizophrenia, several studies identified decreased N1-amplitudes of auditory evoked potentials on EEG and also a decreased activity in certain brain areas. This thesis assessed whether genetic variations associate with the N1-component of auditory evoked potentials in 92 patients
more » ... ials in 92 patients and 254 controls: Two of nine polymorphisms showed significant associations or a trend towards significance in controls and patients with same direction of effect: For SNP rs2551640 the largest amplitude was investigated for genotype A/A and the smallest for G/G. For SNP rs2254137 the maximum amplitude was recorded for genotype A/A and the lowest for C/C. An effect on the N1-amplitude may be possible.
doi:10.25673/2120 fatcat:5nsjkrdyifcu5k2eh4yreb2wu4