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Human Arterial Proteoglycans Increase the Rate of Proteolytic Fusion of Low Density Lipoprotein Particles
Journal of Biological Chemistry
Low density lipoprotein (LDL) particles can undergo fusion in the arterial intima, where they are bound to proteoglycans. Here we studied the effect of human arterial proteoglycans on proteolytic fusion of LDL in vitro. For this purpose, an assay was devised based on fluorescence resonance energy transfer that allowed continuous monitoring of fusion of proteoglycan-bound LDL particles. We found that addition of human arterial proteoglycans markedly increased the rate of proteolytic fusion ofdoi:10.1074/jbc.272.40.25283 pmid:9312145 fatcat:vvb47ebqlvbn7mw3q2nl2pj5yu