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In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
Feedback mechanisms play a critical role in the maintenance of cell homeostasis in the presence of disturbances and uncertainties. Motivated by the need to tune the dynamics and improve the robustness of gene circuits, biological engineers have proposed various designs that mimic natural molecular feedback control mechanisms. However, practical and predictable implementations have proved challenging because of the complexity of synthesis and analysis of complex biomolecular networks. Here, wedoi:10.1038/s41467-019-13626-z pmid:31848346 fatcat:7pqvmdni35bflm3wdyrpm3otwu