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Ion stability of nucleic acids in infrared matrix-assisted laser desorption/ionization mass spectrometry
1993
Nucleic Acids Research
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) with infrared laser light of a wavelength of 2.94 zm has been used for the analysis of nucleic acids. Spectra of oligodeoxynucleotides up to 26 nucleotides, oligothymidylic acids up to 100 nucleotides as well as different synthetic RNA oligomers and RNA transcripts up to 104 nucleotides are presented. A main problem in the analysis of oligodeoxynucleotides was found to be related to the loss of bases. The stability of
doi:10.1093/nar/21.15.3347
pmid:7688451
pmcid:PMC331430
fatcat:exbemggbknh7bdh3dhhtw67ofu