Barium Titanate Nanoparticles for Biomarker Applications

O Matar, O M Posada, N S Hondow, C Wälti, M Saunders, C A Murray, R M D Brydson, S J Milne, A P Brown
2015 Journal of Physics, Conference Series  
A tetragonal crystal structure is required for barium titanate nanoparticles to exhibit the nonlinear optical effect of second harmonic light generation (SHG) for use as a biomarker when illuminated by a near-infrared source. Here we use synchrotron XRD to elucidate the tetragonal phase of commercially purchased tetragonal, cubic and hydrothermally prepared barium titanate (BaTiO 3 ) nanoparticles by peak fitting with reference patterns. The local phase of individual nanoparticles is determined
more » ... icles is determined by STEM electron energy loss spectroscopy (EELS), measuring the core-loss O K -edge and the Ti L 3 -edge energy separation of the t 2g , e g peaks. The results show a change in energy separation between the t 2g and e g peak from the surface and core of the particles, suggesting an intraparticle phase mixture of the barium titanate nanoparticles. HAADF-STEM and bright field TEM-EDX show cellular uptake of the hydrothermally prepared BaTiO 3 nanoparticles, highlighting the potential for application as biomarkers.
doi:10.1088/1742-6596/644/1/012037 fatcat:4emvmakhpzfspaktwciytivinq