Th e aims of this study were to examine what amount of s edentary time is associated with low cardiorespiratory fi tness (CRF) in adolescents and whether this association is independent of physical activity. Methods The study comprised 1808 adolescents aged 12.5-17.5 years from 10 European cities. Sedentary time and moderate-to-vigorous physical activity (MVPA) were measured by accelerometer. CRF was assessed by the 20 m shuttle-run test. Adolescents were divided into two groups (high/low)

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... ding to FITNESSGRAM guidelines. Receiver-operating characteristic (ROC) analysis was used to determine thresholds that best discriminate between high and low CRF in adolescents. Results Adolescent girls had more sedentary time than boys (p<0.001). ROC analysis showed that girls spending ≥69% of waking time in sedentary activities had low CRF, but no signifi cant threshold discriminated between high and low CRF in boys. Adolescent girls who exceeded this threshold had lower levels of CRF (p≤0.001) and were more likely to have a low CRF (OR 1.68, 95% CI 1.22 to 2.31) independent of centre, age and body mass index. The negative infl uence of excessive sedentary time on CRF remained signifi cant (p=0.045) in adolescent girls who did not meet the physical activity guidelines (<60 min/day in MVPA) but was abolished (p>0.05) in those who met the recommendation (≥60 min/day in MVPA). Conclusion Excessive sedentary time is associated with low CRF in adolescent girls but not in boys. However, this adverse effect might be attenuated if adolescent girls meet the current physical activity guidelines.