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Pharmacokinetics of metformin in patients with gastrointestinal intolerance
2018
Diabetes, obesity and metabolism
Aims: Metformin intolerance symptoms are gastrointestinal in nature, but the underlying mechanism is poorly understood. The aim of this study was to assess potential causes of metformin intolerance including: This article is Accepted Article altered metformin uptake from the intestine; increased anaerobic glucose utilisation and subsequent lactate production; altered serotonin uptake; and altered bile acid pool. Methods: This pharmacokinetic study recruited ten severely intolerant and ten
doi:10.1111/dom.13264
pmid:29457876
pmcid:PMC6033038
fatcat:a2qwf5m53ncttlttrgndb4zccu