Phage-based target discovery and its exploitation towards novel antibacterial molecules

Xing Wan, Hanne Hendrix, Mikael Skurnik, Rob Lavigne
2021 Current Opinion in Biotechnology  
The deeply intertwined evolutionary history between bacteriophages and bacteria has endowed phages with highly specific mechanisms to hijack bacterial cell metabolism for their propagation. Here, we present a comprehensive, phage-driven strategy to reveal novel antibacterial targets by the exploitation of phage-bacteria interactions. This strategy will enable the design of small molecules, which mimic the inhibitory phage proteins, and allow the subsequent hit-to-lead development of these
more » ... crobial compounds. This proposed small molecule approach is distinct from phage therapy and phage enzyme-based antimicrobials and may produce a more sustainable generation of new antibiotics that exploit novel bacterial targets and act in a pathogen-specific manner.
doi:10.1016/j.copbio.2020.08.015 pmid:33007632 fatcat:ryed5ag67vacllsupq76fhvghi