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Crystal Structures of F420-dependent Glucose-6-phosphate Dehydrogenase FGD1 Involved in the Activation of the Anti-tuberculosis Drug Candidate PA-824 Reveal the Basis of Coenzyme and Substrate Binding
Journal of Biological Chemistry
The modified flavin coenzyme F 420 is found in a restricted number of microorganisms. It is widely distributed in mycobacteria, however, where it is important in energy metabolism, and in Mycobacterium tuberculosis (Mtb) is implicated in redox processes related to non-replicating persistence. In Mtb, the F 420dependent glucose-6-phosphate dehydrogenase FGD1 provides reduced F 420 for the in vivo activation of the nitroimidazopyran prodrug PA-824, currently being developed for anti-tuberculosisdoi:10.1074/jbc.m801854200 pmid:18434308 fatcat:46hjj6uxpbfwlcfvpayme5cvwq