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Voltage-Gated Ion Channels in Nociceptors: Modulation by cGMP
2004
Journal of Neurophysiology
In tissue or nerve injury, proinflammatory mediators are released that can modulate a variety of ion channels found in nociceptors. The changes in channel activity, which primarily occurs through changes in intracellular pathways, may lead to the pathological states of hyperalgesia and allodynia. To understand further the regulatory mechanisms underlying the changes in channel activity, we used whole cell patch-clamp recordings from capsaicinsensitive nociceptive neurons in rat trigeminal
doi:10.1152/jn.00355.2004
pmid:15175369
fatcat:dhmryxpfxzfinnvxs5h7hpokee