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Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
2019
Nature Communications
In Drosophila melanogaster the single male chromosome X undergoes an average twofold transcriptional upregulation for balancing the transcriptional output between sexes. Previous literature hypothesised that a global change in chromosome structure may accompany this process. However, recent studies based on Hi-C failed to detect these differences. Here we show that global conformational differences are specifically present in the male chromosome X and detectable using Hi-C data on sex-sorted
doi:10.1038/s41467-019-13350-8
pmid:31767860
pmcid:PMC6877619
fatcat:idtow2uugzczxc5rqgbgs5xsfu