Immune-modulation Effect of Ulmus macrocarpa Hance Water Extract on Balb/c Mice
왕느릅나무 껍질 열수 추출물의 마우스에서의 in vivo 면역조절 효과

Inhwan Lee, Da Hye Kwon, Sun Hee Lee, Sung Do Lee, Deok Won Kim, Jong-Hwan Lee, Sook Kyung Hyun, Kyung-Hwa Kang, CheolMin Kim, Byoung Woo Kim, Hye Jin Hwang, Kyung Tae Chung
2014 Journal of Life Science  
Traditional medicinal plants are widely used to treat many diseases, such as inflammation, infections, and even cancer. Ulmus macrocarpa Hance, a Chinese elm species, is distributed in Korea, China, and Japan. The stem bark is widely employed in Korean traditional medicine to treat dermatitis, mastitis, and edema. The aim of this study was to investigate whether water extract of U. macrocarpa Hance bark (Ulmus cortex) has a immune-modulating function in a mouse model. Three different
more » ... ons (30 mg/kg, 100 mg/kg, and 300 mg/kg) of Ulmus cortex water extract (UCWE) were orally administered to mice for 14 days, and their immune responses were analyzed. Cytokines, such as interleukin (IL)-2, IL-12, and IFN-γ, increased in the blood of UCWE-fed groups when compared with a control group. In contrast, the IL-4 level did not change in any of the UCWE-fed groups Cell-mediated cytotoxicity was also assayed using lymphokine-activated killer cells (LAK). LAK showed greater cytotoxicity in the UCWE-fed groups than LAK in the control group. Internal organ indices, such as liver, kidney, spleen, and thymus, were similar in all the groups, including the control group, indicating that UCWE may have been nontoxic in the experimental animals. These data suggest that UCWE has an immune-modulating function in a mouse model.
doi:10.5352/jls.2014.24.10.1151 fatcat:lzi3fwpbhvgg7d5suy7s2uus6i