OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation [article]

JiangMing Huang, MengXi Wu, Yang Zhang, Siyuan Kong, MingQi Liu, BiYun Jiang, Pengyuan Yang, WeiQian Cao
2020 bioRxiv   pre-print
Numerous studies on cancer, biopharmaceuticals, and clinical trials have necessitated comprehensive and precise analysis of protein O-glycosylation. However, the lack of updated and convenient databases deter the storage of and reference to emerging O-glycoprotein data. To resolve this issue, an O-glycoprotein repository named OGP was constructed on the basis of a collection of O-glycoprotein data from different sources. OGP, the largest O-glycoprotein repository thus far, includes 9354
more » ... cludes 9354 O-glycosylation sites and 11633 site-specific O-glycans mapping to 2133 O-glycoproteins. Based on data regarding sites, an O-glycosylation site prediction tool was developed. Moreover, an OGP-based website is already available (http://www.oglyp.org/). This website comprises four functional, specially designed and user-friendly modules: Statistic Analysis, Database Search, Site Prediction and Data Submit. The first version of OGP and the OGP-based website allows users to obtain various data regarding O-glycoproteins, such as protein accession numbers, sequence, site-specific glycan structures, experimental methods, and potential glycosylation sites. Information regarding O-glycosylation mining can be obtained efficiently on this website efficiently, thus greatly facilitating studies on O-glycosylation.
doi:10.1101/2020.03.03.975755 fatcat:cfrjnvdolbbxzcm2qwo7bgxteu