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Hypouricemia is defined when a serum urate concentration is less than or equal 2.0mg/dl. Differential diagnosis is made by fractional uric acid excretion with the identification of urate transporters and intracellular proteins involved in the tubular transport of uric acid. This review examines current knowledge on uric acid tubular transport and the various clinical situations of hypouricemia.doi:10.3265/nefrologia.pre2010.oct.10588 pmid:21270912 fatcat:43xrnnexk5am3o4m62am7yfl2y