Aim: To investigate the early events of bone regeneration of Ca(OH) 2 by studying biochemistry level of alkaline phosphatase (ALP) as guide for bone regeneration. Materials and Methods: The mandible of eight dogs was prepared by hole of 0.5×0.5 cm in depth and diameter in the apical to the molar teeth. This hole packed with Ca(OH) 2 powder mixed with distilled water to become as a paste. Samples of blood were collected pre-operatively considered as control groups [measuring level of serum ALP

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... experimental animals before implanted Ca(OH) 2 ], then at the 7, 10 and 15 day postoperatively considered as treated groups [measuring alteration of level of serum ALP in experimental animals after implanted Ca(OH) 2 ] for biochemical analysis of the level of serum ALP. Results: There was a significant difference at the day 10 following the operation between the control groups and the treated groups, while there was no significant difference at the day 7,and day 15 postoperatively between the control and the treated groups. Also the results showed that there was a high significant difference between the different postoperative days. Conclusion: The (CaOH) 2 powder mixed with distilled water have the ability to accelerate bone regeneration when it is placed in bone defect comparing to that defect filled with nothing.