Trabeculectomy with or without Intraoperative Sub-conjunctival Injection of Bevacizumab in Treating Refractory Glaucoma

Asaad A Ghanem
2011 Journal of Clinical & Experimental Ophthalmology  
Purpose: To evaluate the efficacy of intraoperative sub-conjunctival injection of bevacizumab as an adjunct regiem to trabeculectomy for the treatment of refractory glaucoma. Design: Prospective randomized clinical trial. Patients and Methods: Fifty-five consecutive eyes scheduled for trabeculectomy were randomly included. In the study group (n= 30), bevacizumab (0.05 ml, 1.25 mg) was injected in the sub-conjunctiva adjacent to the bleb using a 30-gauge needle and tuberculin syringe immediately
more » ... syringe immediately after the surgery. In the control group (n= 25) surgery was completed without bevacizumab injection. Surgical success was defined as a complete success if the intraocular pressure (IOP) was 21 mm Hg or less with an IOP reduction of greater than or equal to 20% without anti-glaucoma medications. Success rates in both groups were compared using Kaplan-Meier survival curves and the log-rank test. The morphologic characteristics of the filtering blebs were evaluated using the Indiana Bleb Appearance Grading Scale.
doi:10.4172/2155-9570.1000131 fatcat:3gh4raiylffvbk42inkwif4yga