Neuropharmacological activities of Ficus platyphylla stem bark in mice

OK Wakeel, PI Aziba, RB Ashorobi, S Umukoro, AO Aderibigbe, EO Awe
2010 African Journal of Biomedical Research  
Methanol Extract Ficus platyphylla stem bark in dosages (17, 40 and 75, 150mg/kg) was found to produce a profound decrease in exploratory activity in mice, the extract indicated peripheral and central analgesic effects as shown by significant inhibition of acetic acidinduced writhing, and delayed onset in leptazol induced-convulsion (seizures) in mice respectively. It also decreases the rate of leptazol induced mortality in mice. The totality of these effects showed that the extract possesses
more » ... extract possesses depressant action on the central nervous system.
doi:10.4314/ajbr.v7i2.54073 fatcat:muxjt3xc5navhosqb2t4sqnv2q