Oxidative stress and cytokines have been shown to play a role in the pathogenesis of diabetes. Glycemic variability in patients with type 2 diabetes is clearly associated with oxidative stress, which can be partially explained by epigenetics. The level of oxidative stress in patients with type 1 diabetes is increased, but the relationship between glycemic variability and oxidative stress is not clear, and there may be an autoimmune response involved. Glycemic variability is associated with a

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... iety of cytokines, which play a role in inflammatory response, metabolic disorders, and apoptosis. The effects of glycemic variability on oxidative stress and cytokine and its related mechanisms are reviewed in present paper. DOI: 10.11855/j.issn.0577-7402.2019.12.12