Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing

Young-Soo Kim, Ik-Hyun Cho, Moon-Jin Jeong, Soon-Jeong Jeong, Seung-Yeol Nah, Young-Sik Cho, Seung-Hyun Kim, A-Ra Go, Se-Eun Kim, Seong-Soo Kang, Chang-Jong Moon, Jong-Choon Kim (+2 others)
2011 Journal of Ginseng Research  
In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area and contracture measurements,
more » ... atinocyte migration rate, and calculation of infiltrating inflammatory cells. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds.
doi:10.5142/jgr.2011.35.3.360 pmid:23717081 pmcid:PMC3659532 fatcat:fhqzwv4zhrfzzbd5gj53filxgq