Madhucalongifolia member of the family Sapotaceae was studied for its immunomodulatory activity on albino mice in the present study. The ethanolic extract of the plant (EEML) was administered at the dose of 100 and 200mg/kg body weight in the treated groups III and IV. The antibody titre value, DTH response and effect on myelosuppression were checked against the control group I and cyclophosphomide induced myelosuppressed group II. The significant (p<0.01) increase in antibody titre value and

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... H response in group III & IV was reported as a sign of its stimulating effect on humoral and cell mediated immunity respectively. Moreover, the restoration of Total Leukocyte Count (TLC) and Differential Leukocyte Count (DLC) to normal level in EEML treated group III & IV as compared to cyclophosphomide treated group II has shown it ameliorating effect on myeloid regeneration too. Hence, the M. longifolia with the significant immunostimulatory activity on both the specific and non-specific immune mechanisms holds great promises for being used as an immunomodulating agent. However, more in-depth studies of various other extracts of different parts of the plant may further explore its probability to be used as immunomodulatory drug for the management of infectious diseases.