Genetics of Large Populations and Association Studies [entry]

Lounès Chikhi, Pauline Hélène Garnier-Géré
2006 Encyclopedia of Life Sciences   unpublished
Association studies aim to discover the genetic basis of genetic diseases or drug responses through the comparison of genotypes at marker loci with phenotypes of affected and nonaffected individuals in large populations assumed to be at Hardy-Weinberg equilibrium. Inbreeding; Nonrandom Mating.) Nonrandom mating can be formalized by defining an index, F (Wright, 1951), which quantifies departures from HW proportions: F ¼ ðH obs À H exp Þ=H exp , where H obs is the observed proportion of
more » ... portion of heterozygotes and H exp the proportions expected under
doi:10.1038/npg.els.0005446 fatcat:yryf3knzmzembgjm3iod2hczi4