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Background Headache, one of the most common symptoms presenting to the emergency department, is usually benign but sometimes fatal. Identifying high-risk headache syndromes and providing appropriate headache therapy remain the first priority for emergency physicians. Common "Red flags" includes sudden onset, focal neurological deficit, fever, neck stiffness and so on. We categorize headache into primary (such as tension, cluster headache and migraine) and secondary (subarachnoid hemorrhage,doi:10.21203/rs.3.rs-70086/v1 fatcat:ou6jygg7vbberbueokiobj6fsq