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Summary Digital pathology enables applying computational methods, such as deep learning, in pathology for improved diagnostics and prognostics, but lack of interoperability between whole slide image formats of different scanner vendors is a challenge for algorithm developers. We present OpenPhi - Open PatHology Interface, an Application Programming Interface for seamless access to the iSyntax format used by the Philips Ultra Fast Scanner, the first digital pathology scanner approved by thedoi:10.1093/bioinformatics/btab578 pmid:34358287 pmcid:PMC8570784 fatcat:zv3t3yxfx5h7tljqi4xdespp7m